Making DEWS III Work Without Billing Pitfalls
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DEWS III swapped the treatment ladder for a map. Here’s the management report in five minutes, how to pick a drop for each driver, and how to keep the workflow billable.
The short answer
TFOS DEWS III summary: the 2025 report drops the stepwise severity ladder. Clinicians examine the tear film, eyelids and ocular surface, identify the active drivers, then match evidence-based treatments to each driver. Combination therapy is expected, alongside lifestyle changes and lid hygiene.
If you want a TFOS DEWS III summary you can actually use in clinic, it comes down to one question: what’s driving this patient’s dry eye today? DEWS III moves us away from a rigid stepwise ladder and toward a diagnosis-driven map. Below, I break down the management report, how to choose drops by driver, and what the shift looks like in an independent practice, from foundational care and inflammation to documentation, ocular surface disease evaluations and billing.
Let’s start with the obvious: everyone with eyelids should be cleaning them every single day. At Peeq Pro, we call it “peeqing” your lids, and it’s the foundation of every healthy ocular surface. When the lid margins stay clean and the meibum flows, you’re addressing one of the most basic pieces of ocular surface care.
TFOS DEWS III summary: management at a glance
The TFOS DEWS III Management and Therapy report, published in the American Journal of Ophthalmology in 2025, reviewed more than 1,000 papers. Its biggest change isn’t a new drug. It’s how we decide what to use.
DEWS II gave us a staged, severity-based plan. DEWS III drops it, because patients don’t stay in one category. A patient with lid disease and low tear production can fix the lids with good hygiene, then slide back a month later when the warm compresses stop. Severity labels can’t keep up with that.
Instead, DEWS III gives three algorithms, one for each area you already examine:
- Tear filmIs there a deficiency in the aqueous, lipid or mucin layer?
- EyelidsBlepharitis (including Demodex), MGD, lid wiper epitheliopathy, and blink or lid closure problems.
- Ocular surfaceCorneal and conjunctival staining, plus pterygium, pinguecula or conjunctivochalasis that disrupt the tear film.
Work through all three, list the active drivers, then match a treatment to each one. A single patient might need a lipid-supporting tear, Demodex therapy and a surface procedure at the same time.
Four takeaways that matter most in clinic
- Diagnose before you prescribe. The DEWS III diagnostic algorithm starts with the OSDI-6 questionnaire, then tear film and staining tests. Skip a step and you risk treating the wrong driver.
- Combination therapy is the expectation. Dry eye has multiple pathogenic drivers, so multiple treatments together are often the right plan.
- The foundation still holds. Tear supplements remain the cornerstone of first-line care. The report finds an overall benefit for omega-3s, while optimal source and dose still need study.
- Re-check the drivers at every visit. Treatment, and non-adherence, can change which driver is active. The plan should change with it.
The basics still matter
DEWS III does not mean abandoning conservative care. The foundation still matters, and it can continue alongside more targeted treatment.
- Lid hygiene. Consistent cleansing with a gentle eyelid cleanser remains a core part of supporting the ocular surface and managing the lid margin.
- Warm compresses. At-home heat stays in the conversation, especially when meibomian gland function is part of the picture.
- Omega-3s. Supplementation can remain part of the foundational plan when clinically appropriate for the individual patient.
Related: Are you frustrated with patient compliance? See how patient care kits turn recommendations into something patients actually follow at home.
Want the DEWS foundation first? Understanding dry eye disease and the TFOS DEWS II definition
From a ladder to a map
DEWS II gave us that comforting staircase: start simple, escalate later. Step 1, artificial tears and hygiene. Step 2, maybe a short steroid pulse. Step 3, advanced drops or devices. But the reality? Patients don’t live in steps.
DEWS II: climb the ladder
- Start simple
- Escalate later
- Add more
- Keep escalating
DEWS III: find the driver
What is driving this disease right now?
Some patients walk in with obvious inflammation from day one, with red conjunctiva, punctate staining and angry lid margins, and still get sent home with another bottle of tears. Instead of asking, “What step am I on?” DEWS III has us ask, “What’s driving this disease right now?” Then we treat that driver directly, in context with the rest of the patient’s ocular surface care.
Treat the driver, not the step number.
Drop selection under DEWS III: match the drop to the driver
“Use artificial tears” isn’t a plan anymore. DEWS III links each treatment to the driver it acts on, and that includes the bottle we send patients home with. Over-the-counter tears deserve the same care as a prescription: pick a specific formulation for a specific reason, and write it down.
Aqueous deficiency: replenish, then stimulate
Start with a preservative-free hyaluronic acid tear such as OPTASE Intense, or a higher-viscosity option like Refresh Celluvisc. When the gland needs help, DEWS III’s new neuromodulation section covers acoltremon (Tryptyr) drops and varenicline nasal spray (Tyrvaya) to stimulate natural tear production. Cyclosporine or lifitegrast fits when inflammation is part of the picture.
Lipid deficiency and MGD: slow the evaporation
Reach for a lipid-containing tear such as Systane Complete PF, Refresh Optive Mega-3 or OPTASE MGD Advanced, or prescribe perfluorohexyloctane (Miebo). Drops support the lipid layer, but they don’t open the glands. Heat, expression or in-office treatment still does that work.
Unstable tear film and surface staining: protect and lubricate
Hyaluronic acid and combination-polymer tears are good daily workhorses. When patients wake up gritty, add a bedtime ointment such as OPTASE HYLO Night or Refresh PM, and look for anatomical causes like conjunctivochalasis that drops won’t fix.
Inflammation: calm it, then control it
A short course of a steroid such as loteprednol 0.25% (Eysuvis) can quiet active inflammation. Cyclosporine (Restasis, Cequa, Vevye) or lifitegrast (Xiidra) then supports longer-term control. More on that sequence below.
Demodex blepharitis: treat the lid, not just the tear film
Collarettes are a lid driver, so no tear will solve them. Lotilaner 0.25% (Xdemvy) targets the mites directly. Daily lid hygiene with a gentle eyelid cleanser keeps debris down during and after treatment.
Neural dysregulation: know when drops aren’t the answer
When symptoms far outweigh the signs, the driver may be neuropathic. More drops rarely help that patient. Measure corneal sensation, and treat or refer for the pain component.
Preservative-free drops to name, by job
OPTASE IntenseHyaluronic acid hydration for aqueous deficiencyView drop
Refresh CelluviscHigher viscosity when tears don’t lastView drop
Systane Complete PFLipid support for evaporative dry eye and MGDView drop
OPTASE HYLO NightBedtime protection for unstable tear filmView drop
See the full lineup in our eye drops collection.
Three drop rules that save you a follow-up visit
- Name the bottle. Recommend one specific tear, not a category. You can’t judge a trial if the patient bought whatever was on sale.
- Go preservative-free for frequent use. Patients dosing more than four times a day, or using several drops, should avoid preserved formulas.
- Document the trial. Many prescription prior authorizations require a documented artificial tear trial first. A named tear, dose and start date in the chart makes the OSDE and the PA easier.
Go deeper on drops: Which eye drop should I recommend? Matching artificial tears to dry eye symptoms, and Dr. Chris Wolfe on why the best artificial tear is the one his patient eventually doesn’t need.
Inflammation: act early, then think long-term
Inflammation is a common thread across many dry eye presentations, whether the patient is aqueous-deficient, evaporative, mixed, or dealing with a more complex pain component. DEWS III supports addressing it earlier, instead of waiting for a patient to “fail” a series of conservative steps first.
- Identify active inflammation. Recognize inflammatory signs and symptoms as part of the patient’s current disease picture.
- Calm the cycle. Use short-term anti-inflammatory management when clinically appropriate to quiet the active process.
- Maintain control. Transition toward a longer-term plan based on the patient’s ongoing drivers and needs.
Keep the foundation running alongside it: lid hygiene, warm compresses, omega-3s, hydration and environment.
“It’s not ‘Step 1 or Step 2.’ It’s ‘What’s active today, and how can I quiet it down?’”
The clinical plan is only half the equation
Here’s where the clinical meets the bureaucratic. A comprehensive exam, often billed under a vision plan, is not the same as a medical management visit. If you identify dry eye, educate the patient, and move immediately into full medical management under the comprehensive exam, you can create billing and documentation problems.
So how do we practice an integrated DEWS III model without tripping over billing rules? Split the process, not the care.
Need the coding side broken down? Dr. Christopher Wolfe walks through OSDEs, E/M coding, G2211, diagnostic testing, staff communication and Medicare considerations in Billing and coding dry eye like a pro.
Separate the visits without disconnecting the care
The goal is not to delay appropriate care. It’s to create a clinical and documentation sequence that makes sense for both the patient and the chart.
Visit 1: comprehensive eye exam
- Identify signs and symptoms
- Review staining, gland findings and tear stability
- Educate on foundational care
- Start lid hygiene, warm compresses and a named artificial tear
- Document everything clearly
Visit 2: ocular surface disease evaluation
- Reassess the patient’s response
- Identify the active disease drivers
- Add prescription management when appropriate
- Add objective testing when clinically indicated
- Bill according to the services and complexity provided
After a period of consistent self-care, reassess. If inflammation or other signs remain active, you now have a clearer clinical picture and a documented rationale for moving further into medical management. Sometimes that window will be shorter because the patient needs more immediate intervention. The point isn’t to force every patient into the same timeline. It’s to keep a clear, defensible care sequence.
Follow the map, not the ladder
DEWS III doesn’t erase the fundamentals. It validates the reality that dry eye is multifactorial, dynamic and highly individual. Patients don’t want a “step plan.” They want a plan that reflects what is happening with their eyes today.
Clinically, that means treating the patient in front of you. Operationally, it means giving the practice a repeatable path: a defined identification visit, a follow-up point, a documentation standard and a care pathway the whole team understands. Split your billing process when needed, but don’t split your clinical logic.
Want to hear how Dr. Chapman actually does this?
DEWS III is one thing on paper. Building the workflow around it in a real practice is another. If you’re thinking through your dry eye program, patient journey, at-home care or team handoffs, we’d love to talk it through.
Schedule a call See how custom kits workTFOS DEWS III and dry eye strategy FAQs
What is a quick TFOS DEWS III summary?
TFOS DEWS III replaces the stepwise, severity-based plan with three algorithms covering the tear film, eyelids and ocular surface. Clinicians identify each active driver and match an evidence-based treatment to it, often combining several treatments at once.
What changed from DEWS II to DEWS III?
DEWS II used a single staged algorithm built around severity and the aqueous-deficient versus evaporative split. DEWS III replaces it with three driver-based algorithms, because patients move between categories as treatment and adherence change.
How should I choose dry eye drops under DEWS III?
Match the drop to the driver. Preservative-free hyaluronic acid or higher-viscosity tears suit aqueous deficiency, lipid-containing tears or perfluorohexyloctane suit evaporative and MGD-driven disease, and anti-inflammatory or anti-Demodex prescriptions address those specific drivers.
Do artificial tears still matter in DEWS III?
Yes. The report calls tear supplements the cornerstone of first-line management. The change is that the tear should be chosen for a specific driver and documented, not recommended as a generic category.
What are the three DEWS III treatment algorithms?
One covers tear film deficiencies (aqueous, lipid, mucin), one covers eyelid anomalies (blepharitis, Demodex, MGD, lid closure), and one covers ocular surface abnormalities such as staining, pterygium or conjunctivochalasis.
Does foundational dry eye care still matter under DEWS III?
Yes. Lid hygiene, warm compresses, omega-3 supplementation when appropriate, hydration and environmental changes continue as foundational care even when more targeted therapies are added.
How does inflammation fit into DEWS III dry eye management?
When inflammatory signs are clearly active, treatment may need to address that inflammation earlier rather than waiting for the patient to work through a rigid sequence of conservative steps.
What is an ocular surface disease evaluation (OSDE)?
An OSDE is a dedicated follow-up visit used to reassess the patient, identify active disease drivers, add medical treatment or testing when appropriate, and document ongoing management of the condition.
Why separate the comprehensive exam from the dry eye visit?
Separating them keeps billing and documentation clean while the clinical care stays connected. The comprehensive exam identifies the problem and starts foundational care, and the follow-up supports focused medical management.
How can practices improve follow-through on dry eye care?
Clear education, consistent team messaging, simple at-home routines and organized access to the recommended products, such as custom patient care kits, make the plan easier for patients to follow.
Cheryl Chapman, OD, FAAO, IACMM, FIAOMC, Diplomate ABO
Dr. Chapman is an optometrist, dry eye expert, specialty contact lens clinician and co-founder of Peeq Pro. Her work spans advanced ocular surface care, specialty lenses, myopia management, and the systems that help independent practices turn recommendations into consistent patient care.
Clinical education only. Treatment should be individualized by the treating eye care professional and follow current product labeling. Product names are trademarks of their respective owners; mentions are examples, not endorsements of one brand over another. Source: Jones L, Craig JP, Markoulli M, et al. TFOS DEWS III: Management and Therapy. Am J Ophthalmol. 2025;279:289–386.