Dupixent (dupilumab) has become a game-changing medication for people suffering from chronic conditions like atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis. While it's highly effective for these conditions, some users report an unexpected and frustrating side effect: dry eye.

In this post, we’ll explore why dry eye symptoms can arise when using Dupixent, and how simple yet consistent eye care routines – like using nighttime ointments (such as Refresh PM or Optase Hylo Night), daily eye drops for dry eye, and practicing eyelid hygiene – can significantly improve comfort and eye health.

Understanding the Link Between Dupixent and Dry Eye

Dry eye is a documented side effect of Dupixent, especially in people taking it for atopic dermatitis. In clinical trials for eczema, conjunctivitis and dry eye symptoms occurred significantly more frequently in Dupixent users compared to those receiving a placebo. Why does this happen?

Dupixent works by modulating the immune system, specifically inhibiting the interleukin-4 and interleukin-13 pathways. While this helps reduce inflammation in the skin and airways, it may also disrupt the delicate balance of the ocular surface and tear film. The result? Reduced tear production or changes in tear quality, leading to dry, irritated, and inflamed eyes.

Signs of Dry Eye Associated with Dupixent

If you're using Dupixent and experiencing any of the following, you may be dealing with dry eye:

• Burning, stinging, or gritty sensation in the eyes
• Itchiness
• Redness or inflammation
• Blurred vision, especially after extended screen time
• Eye fatigue or excessive tearing (a paradoxical symptom of dry eye)

The good news is that there are several ways to manage these symptoms and protect your eye health.

How to Alleviate Dupixent Related Dry Eye

1. Use Lubricating Eye Drops Regularly

Over-the-counter artificial tears can help replenish moisture and restore balance to the ocular surface. Look for preservative-free drops, especially if you need to use them multiple times a day. Products like Refresh Optive Mega-3, Optase Dry Eye Intense, or Systane Complete PF are popular choices.

2. Nighttime Relief with a Nighttime Ointment

Treating your dry eye overnight when it occurs due to side effects from another medicine has been shown to be particularly helpful.

If your eyes feel especially dry overnight or upon waking up in the morning, consider using Refresh PM or Optase Hylo Night. These are lubricating eye ointments designed for nighttime use. They create a moisture-sealing barrier that protects your eyes while you sleep, helping you wake up with less irritation and dryness.

3. Practice Daily Eyelid Hygiene

Maintaining eyelid hygiene is crucial, especially since inflammation of the eyelids (blepharitis) can worsen dry eye symptoms. Use warm compresses for 5–10 minutes daily, followed by a gentle cleansing of the eyelid margins with a product like a tea tree oil based cleanser, such as Peeq Pro’s Foaming Eyelid and Facial Cleanser or hypochlorous acid spray, such as Pure&Clean’s Lid Prep Spray.

This routine helps unclog meibomian glands, which are essential for a healthy tear film. We particularly recommend using the tea tree oil foaming cleanser in the shower. It helps make the peeqing behavior routine.

When to Talk to Your Doctor

While these treatments can offer relief, persistent or worsening dry eye symptoms should be evaluated by an optometrist or ophthalmologist. In some cases, prescription eye drops like Restasis, Xiidra, or steroid drops may be needed. Your doctor may also recommend adjusting your Dupixent dosage or frequency if dry eye is significantly affecting your quality of life.

Final Thoughts

While Dupixent can greatly improve skin and respiratory conditions, dry eye is a common and manageable side effect. With consistent use of lubricating eye drops like Refresh Optive Mega-3, nighttime products like Refresh PM, and diligent eyelid hygiene, you can protect your vision and keep your eyes feeling comfortable.

If you’re struggling with dry eye while using Dupixent, you’re not alone – and relief is within reach.